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The most recent positive reports about erhhte a2-adrenoceptor density in depression have used agonist radioligand binding assays. 3H agonists label predominantly the high state Affinitt a2 adreno receptors egulatorische to guanine nucleotide-binding proteins ???? ???? G-proteins) (Hoffman and Lef Kowitz coupled Thomsen 1980 ;. et al 1988, Kafka and Paul 1986 berprft ;. Piletz et al 1991). 3H-antagonist, dubai airshow 2011 on the other hand, have not been shown to identify differences in the cx2 adrenoceptor in depression, and this means both high and low Affinitt States of the a2 adrenoceptor (Asakura et al. 1985). On the basis of these differences, radioligand binding, Garcia Sevilla dubai airshow 2011 et al. (1986) have hypothesized that a Reinforced coupling of the high Affinitt a2-adrenoceptor state knnte receptor hypersensitivity dubai airshow 2011 in the underlying depression.
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